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Synthetic Mimic of Antimicrobial Peptide with Nonmembrane-Disrupting Antibacterial Properties

Polyguanidinium oxanorbornene (PGON) was synthesized from norbornene monomers via ring-opening metathesis polymerization. This polymer was observed to be strongly antibacterial against Gram-negative and Gram-positive bacteria as well as nonhemolytic against human red blood cells. Time-kill studies i...

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Published in:	Biomacromolecules 2008-11, Vol.9 (11), p.2980-2983
Main Authors:	Gabriel, Gregory J, Madkour, Ahmad E, Dabkowski, Jeffrey M, Nelson, Christopher F, Nüsslein, Klaus, Tew, Gregory N
Format:	Article
Language:	English
Subjects:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antimicrobial Cationic Peptides Applied sciences Communication Erythrocytes - drug effects Exact sciences and technology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Guanidines - chemistry Guanidines - pharmacology Humans Microbial Sensitivity Tests Molecular Mimicry Organic polymers Physicochemistry of polymers Polymers - chemistry Polymers - pharmacology Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts
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creator	Gabriel, Gregory J Madkour, Ahmad E Dabkowski, Jeffrey M Nelson, Christopher F Nüsslein, Klaus Tew, Gregory N
description	Polyguanidinium oxanorbornene (PGON) was synthesized from norbornene monomers via ring-opening metathesis polymerization. This polymer was observed to be strongly antibacterial against Gram-negative and Gram-positive bacteria as well as nonhemolytic against human red blood cells. Time-kill studies indicated that this polymer is lethal and not just bacteriostatic. In sharp contrast to previously reported SMAMPs (synthetic mimics of antimicrobial peptides), PGON did not disrupt membranes in vesicle-dye leakage assays and microscopy experiments. The unique biological properties of PGON, in same ways similar to cell-penetrating peptides, strongly encourage the examination of other novel guanidino containing macromolecules as powerful and selective antimicrobial agents.
doi_str_mv	10.1021/bm800855t
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source	American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antimicrobial Cationic Peptides Applied sciences Communication Erythrocytes - drug effects Exact sciences and technology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Guanidines - chemistry Guanidines - pharmacology Humans Microbial Sensitivity Tests Molecular Mimicry Organic polymers Physicochemistry of polymers Polymers - chemistry Polymers - pharmacology Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts
title	Synthetic Mimic of Antimicrobial Peptide with Nonmembrane-Disrupting Antibacterial Properties
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