Rh(I)-Catalyzed Direct Arylation of Pyridines and Quinolines

A Rh(I)-catalyzed direct arylation of pyridine and quinoline heterocycles has been developed. The method provides rapid entry into an important class of substituted heterocycles employing inexpensive and readily available starting materials.

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Bibliographic Details
Published in:Journal of the American Chemical Society 2008-11, Vol.130 (45), p.14926-14927
Main Authors: Berman, Ashley M, Lewis, Jared C, Bergman, Robert G, Ellman, Jonathan A
Format: Article
Language:English
Subjects:
37
ADDITIVES
ALKENES
ALKYLATION
AROMATICS
ARYLATION
Benzene Derivatives - chemical synthesis
Benzene Derivatives - chemistry
BROMIDES
Catalysis
CATALYSTS
HALIDES
NUCLEI
PHOSPHINES
PHOSPHOROUS ACID
PICOLINES
PYRIDINE
PYRIDINES
Pyridines - chemical synthesis
Pyridines - chemistry
QUINOLINES
Quinolines - chemical synthesis
Quinolines - chemistry
Rhodium - chemistry
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Description
Summary:A Rh(I)-catalyzed direct arylation of pyridine and quinoline heterocycles has been developed. The method provides rapid entry into an important class of substituted heterocycles employing inexpensive and readily available starting materials.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja8059396