Identification of Hepatitis B Virus Indigenous to Chimpanzees

Hepatitis B viruses (HBV) and related viruses, classified in the Hepadnaviridae family, are found in a wide variety of mammals and birds. Although the chimpanzee has been the primary experimental model of HBV infection, this species has not been considered a natural host for the virus. Retrospective...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2000-02, Vol.97 (4), p.1661-1664
Main Authors: Hu, Xiaolei, Margolis, Harold S., Purcell, Robert H., Ebert, James, Robertson, Betty H.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Animals
Biological Sciences
Chimpanzees
DNA, Viral - genetics
Evolution
Genetics
Genome, Viral
Genomes
Genotype
Genotypes
Hepadnaviridae
Hepadnaviridae Infections
Hepatitis
Hepatitis antigens
Hepatitis B
hepatitis B surface antigen
Hepatitis B virus
Hepatitis B virus - genetics
Humans
Infections
Molecular Sequence Data
Monkeys & apes
Pan troglodytes - virology
Phylogeny
Primates
S gene
Sequence Analysis
Sequence Homology, Amino Acid
Viral Proteins - chemistry
Viral Proteins - genetics
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Summary:Hepatitis B viruses (HBV) and related viruses, classified in the Hepadnaviridae family, are found in a wide variety of mammals and birds. Although the chimpanzee has been the primary experimental model of HBV infection, this species has not been considered a natural host for the virus. Retrospective analysis of 13 predominantly wild-caught chimpanzees with chronic HBV infection identified a unique chimpanzee HBV strain in 11 animals. Nucleotide and derived amino acid analysis of the complete HBV genome and the gene coding for the hepatitis B surface antigen (S gene) identified sequence patterns that could be used to reliably identify chimpanzee HBV. This analysis indicated that chimpanzee HBV is distinct from known human HBV genotypes and is closely related to HBVs previously isolated from a chimpanzee, gibbons, gorillas, and orangutans.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.97.4.1661