Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma

Head and neck squamous cell carcinomas (HNSCCs) represent clinically and etiologically heterogeneous tumors affecting >40 000 patients per year in the USA. Previous research has identified individual epigenetic alterations and, in some cases, the relationship of these alterations with carcinogen...

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Bibliographic Details
Published in:Carcinogenesis (New York) 2009-03, Vol.30 (3), p.416-422
Main Authors: Marsit, Carmen J., Christensen, Brock C., Houseman, E. Andres, Karagas, Margaret R., Wrensch, Margaret R., Yeh, Ru-Fang, Nelson, Heather H., Wiemels, Joseph L., Zheng, Shichun, Posner, Marshall R., McClean, Michael D., Wiencke, John K., Kelsey, Karl T.
Format: Article
Language:English
Subjects:
Aged
Alcohol Drinking - adverse effects
Biological and medical sciences
Biomarkers, Tumor - metabolism
Cancer Biology
Carcinogenesis, carcinogens and anticarcinogens
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
CpG Islands
DNA Methylation - genetics
DNA Methylation - physiology
Epigenesis, Genetic
Female
Gene Expression Profiling - methods
Head and Neck Neoplasms - etiology
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - metabolism
Humans
Male
Medical sciences
Middle Aged
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Smoking - adverse effects
Tumors
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Summary:Head and neck squamous cell carcinomas (HNSCCs) represent clinically and etiologically heterogeneous tumors affecting >40 000 patients per year in the USA. Previous research has identified individual epigenetic alterations and, in some cases, the relationship of these alterations with carcinogen exposure or patient outcomes, suggesting that specific exposures give rise to specific types of molecular alterations in HNSCCs. Here, we describe how different etiologic factors are reflected in the molecular character and clinical outcome of these tumors. In a case series of primary, incident HNSCC (n = 68), we examined the DNA methylation profile of 1413 autosomal CpG loci in 773 genes, in relation to exposures and etiologic factors. The overall pattern of epigenetic alteration could significantly distinguish tumor from normal head and neck epithelial tissues (P 
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/bgp006