MSC response to pH levels found in degenerating intervertebral discs

Painful degenerative disc disease is a major health problem and for successful tissue regeneration, MSCs must endure and thrive in a harsh disc microenvironment that includes matrix acidity as a critical factor. MSCs were isolated from bone marrow of Sprague–Dawley rats from two different age groups...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2009-02, Vol.379 (4), p.824-829
Main Authors: Wuertz, Karin, Godburn, Karolyn, Iatridis, James C.
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
AGE GROUPS
Ageing
Aggrecans - genetics
Animals
BONE MARROW
Cell Culture Techniques
CELL PROLIFERATION
Cell Survival
COLLAGEN
Collagen Type I - genetics
DNA - analysis
DNA - metabolism
Fluoresceins - chemistry
Gene Expression
GENES
Hydrogen-Ion Concentration
INHIBITION
Intervertebral disc
Intervertebral Disc - metabolism
Intervertebral Disc - pathology
Intervertebral Disc - physiology
Mesenchymal Stem Cell Transplantation
Mesenchymal stem cells
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
MORPHOLOGY
Organic Chemicals - chemistry
PH VALUE
Proliferation
Propidium - chemistry
RATS
Rats, Sprague-Dawley
REGENERATION
SKELETAL DISEASES
Spinal Diseases - metabolism
Spinal Diseases - pathology
Spinal Diseases - surgery
STEM CELLS
Tissue Engineering
Tissue Inhibitor of Metalloproteinase-3 - genetics
VERTEBRAE
VIABILITY
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Description
Summary:Painful degenerative disc disease is a major health problem and for successful tissue regeneration, MSCs must endure and thrive in a harsh disc microenvironment that includes matrix acidity as a critical factor. MSCs were isolated from bone marrow of Sprague–Dawley rats from two different age groups (
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2008.12.145