Duration of breast feeding and arterial distensibility in early adult life: population based study

• Published in: BMJ 2001-03, Vol.322 (7287), p.643-647
• Main Authors: Leeson, C P M, Kattenhorn, M, Deanfield, J E, Lucas, A
• Format: Article
• Language: English
• Subjects: Adult; Adults; Age Factors; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood pressure; Body mass index; Brachial Artery - physiology; Breast Feeding - adverse effects; Breastfeeding; Breastfeeding & lactation; Cambridge; Cardiology. Vascular system; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - etiology; Cholesterol; Cholesterol - blood; Cholesterols; Cohort Studies; Duration; England; Female; Humans; Hypotheses; Infancy; Infant; Infant, Newborn; Influence; Linear Models; Lipids; Male; Medical research; Medical sciences; Mens health; Myocardial ischemia; Nutrition; Nutrition research; Observational research; Predisposing factors; Questionnaires; Regression coefficients; Risk Factors; Studies; Variables; Vasodilation - physiology; Womens health
• ISSN: 0959-8138; 0959-8146; 0959-535X; 1468-5833; 1756-1833
• DOI: 10.1136/bmj.322.7287.643

Abstract Objectives: To test the hypothesis that duration of breast feeding is related to changes in vascular function relevant to the development of cardiovascular disease. Design: Population based observational study. Setting: Cambridge. Participants: 331 adults (171 women, 160 men) aged between 20 and 28 years, born in Cambridge Maternity Hospital. Main outcome measures: Distensibility of brachial artery, type and duration of infant feeding, current lipid profile, and other cardiovascular risk factors. Results: The longer the period of breast feeding the less distensible the artery wall in early adult life, with no sex differences (regression coefficient = —3.93 μm/month, 95% confidence interval —7.29 to —0.57, P=0.02). However, in those breast fed for less than four months, arterial distensibility was not significantly reduced compared with an exclusively formula fed group. The vascular changes observed were not explained by alterations in plasma cholesterol concentration in adult life. Conclusions: Breast feeding in infancy is related to reduced arterial function 20 years later. These data should not alter current recommendations in favour of breast feeding, which has several benefits for infant health. Further work is needed, however, to explore the optimal duration of breast feeding in relation to cardiovascular outcomes.