Biological Approaches to Mechanistically Understand the Healthy Life Span Extension Achieved by Calorie Restriction and Modulation of Hormones

Calorie restriction and reduced somatotropic (growth hormone and insulin-like growth factor-1) signaling have a widespread though not universal ability to extend life. These interventions are considered central tools to understanding the downstream events that lead to the increase in healthy life sp...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2009-02, Vol.64A (2), p.187-191
Main Authors: Barzilai, Nir, Bartke, Andrzej
Format: Article
Language:English
Subjects:
Age
Aging
Aging - metabolism
Aging - physiology
Animals
Biology
Caloric restriction
Caloric Restriction - methods
Clinical trials
Diet
Geriatrics - standards
Geriatrics - trends
Growth hormone
Growth Hormone - metabolism
Growth hormones
Health Status
Healthylife span
Humans
Insolin-Like growth fact
Insulin-Like Growth Factor I - metabolism
Journal of Gerontology: Biological Sciences
Laboratory animals
Life Expectancy
Life Style
Longevity - physiology
Low density lipoprotein
Mice
Models, Animal
Nutrition research
Plasma
Risk factors
Sensitivity and Specificity
Smoking
Transgenic animals
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Summary:Calorie restriction and reduced somatotropic (growth hormone and insulin-like growth factor-1) signaling have a widespread though not universal ability to extend life. These interventions are considered central tools to understanding the downstream events that lead to the increase in healthy life span. As these approaches have been validated, the animals phenotyped, and the mechanisms proposed, many challenges have emerged. In this article, we give several examples and propose several considerations, opportunities, and approaches that may identify major mechanisms through which these interventions exert their effects, and which may lead to drug therapy to increase “health span.”
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/gln061