Using the literature-based discovery paradigm to investigate drug mechanisms

Drug therapies are often used effectively without their underlying mechanism being completely understood. We exploit the literature-based discovery paradigm to investigate these mechanisms and propose a discovery pattern that draws on semantic predications extracted from MEDLINE citations. The use o...

Full description

Saved in:
Bibliographic Details
Published in:AMIA ... Annual Symposium proceedings 2007-10, Vol.2007, p.6-10
Main Authors: Ahlers, Caroline B, Hristovski, Dimitar, Kilicoglu, Halil, Rindflesch, Thomas C
Format: Article
Language:English
Subjects:
Antipsychotic Agents - pharmacology
Antipsychotic Agents - therapeutic use
Brain-Derived Neurotrophic Factor - metabolism
Cytochrome P-450 CYP2D6 - genetics
Cytochrome P-450 CYP2D6 - metabolism
Humans
Information Storage and Retrieval
MEDLINE
Natural Language Processing
Neoplasms - drug therapy
Prolactin - genetics
Prolactin - metabolism
Receptors, Glucocorticoid - metabolism
Semantics
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - metabolism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Drug therapies are often used effectively without their underlying mechanism being completely understood. We exploit the literature-based discovery paradigm to investigate these mechanisms and propose a discovery pattern that draws on semantic predications extracted from MEDLINE citations. The use of semantic predications and the discovery pattern provides a way to uncover previously unnoticed associations between pharmacologic and bioactive substances on the one hand and bioactive substances and disorders on the other. In this paper, we concentrate on research investigating the use of antipsychotic agents used for treatment of cancer. Our method resulted in five biomolecules that may provide a link between the antipsychotic agents and cancer: brain-derived neurotrophic factor, CYP2D6, glucocorticoid receptor, PRL, and TNF.
ISSN:1559-4076