NOD-like receptors and inflammation

The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare monogenic disease...

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Bibliographic Details
Published in:Arthritis research & therapy 2008-01, Vol.10 (6), p.228-228
Main Authors: Mathews, Rebeccah J, Sprakes, Michael B, McDermott, Michael F
Format: Article
Language:English
Subjects:
Animals
Humans
Inflammation Mediators - metabolism
Inflammation Mediators - physiology
Mutation
Nod Signaling Adaptor Proteins - genetics
Nod Signaling Adaptor Proteins - physiology
Review
Signal Transduction - genetics
Signal Transduction - immunology
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Summary:The nucleotide-binding and oligomerization domain, leucine-rich repeat (also known as NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare monogenic diseases, as well as some more common polygenic conditions. Bacterial wall constituents and other cellular stressor molecules are recognized by a range of NLRs, which leads to activation of the innate immune response and upregulation of key proinflammatory pathways, such as IL-1beta production and translocation of nuclear factor-kappaB to the nucleus. These signalling pathways are increasingly being targeted as potential sites for new therapies. This review discusses the role played by NLRs in a variety of inflammatory diseases and describes the remarkable success to date of these therapeutic agents in treating some of the disorders associated with aberrant NLR function.
ISSN:1478-6354
1478-6362
DOI:10.1186/ar2525