Intermittent active motion versus immobilization in the treatment of Staphylococcus aureus-induced arthritis in a rabbit model

Abstract Purpose This study has evaluated the effects of immobilization versus intermittent active motion on cartilage and on antibiotic efficacy in a rabbit septic arthritis model. Methods Rabbits were infected and assigned to one of four groups: group 1, no treatment without immobilization (allowi...

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Bibliographic Details
Published in:Journal of children's orthopaedics 2008-12, Vol.2 (6), p.491-495
Main Authors: Hamel, Antoine, Caillon, Jocelyne, Jacqueline, Cédric, Batard, Eric, Boutoille, David, Bugnon, Denis, Miégeville, Anne-Françoise, Rogez, Jean-Michel, Potel, Gilles
Format: Article
Language:English
Subjects:
Antimicrobial agents
Arthritis
Basic Science
Cartilage
Chemotherapy
Fentanyl
General anesthesia
Medical prognosis
Medicine
Medicine & Public Health
Orthopedics
Pediatrics
Physiology
Standard deviation
Traumatic Surgery
Variance analysis
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Summary:Abstract Purpose This study has evaluated the effects of immobilization versus intermittent active motion on cartilage and on antibiotic efficacy in a rabbit septic arthritis model. Methods Rabbits were infected and assigned to one of four groups: group 1, no treatment without immobilization (allowing intermittent active motion); group 2, cast; group 3, oxacillin without immobilization; group 4, oxacillin and cast. Animals were sacrificed 21 days later. Bacterial counts and lateral radiograms were performed. A radiological score was calculated. Results Immobilization had no effect on oxacillin efficacy and a deleterious effect on the radiological score. Conclusion Intermittent active motion has allowed a better cartilage healing during the treatment of septic arthritis.
ISSN:1863-2521
1863-2548
DOI:10.1007/s11832-008-0128-7