Intravenous and nebulised magnesium sulphate for acute asthma: systematic review and meta-analysis

Objectives:To estimate the effect of intravenous and nebulised magnesium sulphate upon hospital admissions and pulmonary function in adults and children with acute asthma.Methods:We undertook a systematic review and meta-analysis of randomised and quasi-randomised trials of intravenous or nebulised...

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Bibliographic Details
Published in:Emergency medicine journal : EMJ 2007-12, Vol.24 (12), p.823-830
Main Authors: Mohammed, S, Goodacre, S
Format: Article
Language:English
Subjects:
Acute Disease
Administration, Inhalation
Adolescent
Adult
Adults
Aged
Aged, 80 and over
Anti-Asthmatic Agents - administration & dosage
Anti-Asthmatic Agents - therapeutic use
Asthma
Asthma - drug therapy
Child
Drug dosages
Emergency medical care
Female
Hospitalization - statistics & numerical data
Hospitals
Humans
Immunology
Injections, Intravenous
Magnesium
Magnesium Sulfate - administration & dosage
Magnesium Sulfate - therapeutic use
Male
Medicine
Middle Aged
Nebulizers and Vaporizers
Original
Patient admissions
Randomized Controlled Trials as Topic
Studies
Treatment Outcome
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Summary:Objectives:To estimate the effect of intravenous and nebulised magnesium sulphate upon hospital admissions and pulmonary function in adults and children with acute asthma.Methods:We undertook a systematic review and meta-analysis of randomised and quasi-randomised trials of intravenous or nebulised magnesium sulphate in acute asthma. Trials were identified by searches of the electronic literature, relevant journal websites and conference proceedings, and contact with authors and experts. Data were pooled using random effects meta-analysis of the relative risk (RR) of hospital admission and the standardised mean difference (SMD) in pulmonary function.Results:24 studies (15 intravenous, 9 nebulised) incorporating 1669 patients were included. Intravenous treatment was associated in adults with weak evidence of an effect upon respiratory function (SMD 0.25, 95% confidence interval (CI) −0.01 to 0.51; p = 0.05), but no significant effect upon hospital admission (RR 0.87, 95% CI 0.70 to 1.08; p = 0.22), and in children with a significant effect upon respiratory function (SMD 1.94, 95% CI 0.80 to 3.08; p
ISSN:1472-0205
1472-0213
DOI:10.1136/emj.2007.052050