Frequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulation

The molecular pathogenesis of gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) remains to be elucidated. High-mobility group A (HMGA) proteins play important roles in the regulation of transcription, differentiation, and neoplastic transformation. In this study, the expression of HMGA1 and...

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Bibliographic Details
Published in:British journal of cancer 2009-02, Vol.100 (3), p.501-510
Main Authors: Rahman, M M, Qian, Z R, Wang, E L, Sultana, R, Kudo, E, Nakasono, M, Hayashi, T, Kakiuchi, S, Sano, T
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer Research
Digestive System Neoplasms - genetics
Down-Regulation
Drug Resistance
Epidemiology
HMGA Proteins - genetics
Humans
Immunohistochemistry
Medical research
MicroRNAs
MicroRNAs - genetics
Molecular Diagnostics
Molecular Medicine
Neuroendocrine tumors
Neuroendocrine Tumors - genetics
Oncology
Pathogenesis
Pathology
Proteins
Reverse Transcriptase Polymerase Chain Reaction
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Summary:The molecular pathogenesis of gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) remains to be elucidated. High-mobility group A (HMGA) proteins play important roles in the regulation of transcription, differentiation, and neoplastic transformation. In this study, the expression of HMGA1 and HMGA2 was studied in 55 GEP NETs. Overexpression of HMGA1 and 2 was frequently detected in GEP NETs compared with normal tissues. Nuclear immunostaining of HMGA1 and 2 was observed in GEP NETs (38 of 55, 69%; 40 of 55, 73%, respectively). High-mobility group A2 expression increased from well-differentiated NET (WNET) to well-differentiated neuroendocrine carcinoma (WNEC) and poorly differentiated NEC (PNEC) ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6604883