Clinical Recovery in First-Episode Psychosis

Introduction: Generally agreed outcome criteria in psychosis are required to evaluate the effectiveness of new treatment strategies. The aim of this study is to explore clinical recovery in first-episode patients, defined by meeting criteria for both symptomatic and functional remission. Method: In...

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Bibliographic Details
Published in:Schizophrenia bulletin 2009-03, Vol.35 (2), p.362-369
Main Authors: Wunderink, Lex, Sytema, Sjoerd, Nienhuis, Fokko J., Wiersma, Durk
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antipsychotic Agents - therapeutic use
Female
Follow-Up Studies
Humans
Male
Middle Aged
Outcome Assessment (Health Care)
Prognosis
Psychiatric Status Rating Scales
Psychosis
Psychotic Disorders - diagnosis
Psychotic Disorders - drug therapy
Psychotic Disorders - psychology
Quality of Life
Schizophrenia - drug therapy
Schizophrenic Psychology
Social Adjustment
Theme: Functional Recovery in Schizophrenia: Raising the Bar for Outcomes in People with Schizophrenia Guest Editor: Philip D. Harvey
Time Factors
Treatment Outcome
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Summary:Introduction: Generally agreed outcome criteria in psychosis are required to evaluate the effectiveness of new treatment strategies. The aim of this study is to explore clinical recovery in first-episode patients, defined by meeting criteria for both symptomatic and functional remission. Method: In a sample of first-episode patients (N = 125), symptomatic and functional remission during the last 9 months of a 2-year follow-up period were examined, as well as recovery and its predictors. Results: Half the patients (52.0%) showed symptomatic remission and a quarter (26.4%) functional remission, while one-fifth (19.2%) met both criteria sets and were considered recovered. Recovery was significantly associated with short duration of untreated psychosis and better baseline functioning. Conclusion: Most functionally remitted patients were also symptomatically remitted, while a minority of symptomatically remitted patients were also functionally remitted. Treatment delay may affect chance of recovery.
ISSN:0586-7614
1745-1701
DOI:10.1093/schbul/sbn143