Roles of the Werner syndrome RecQ helicase in DNA replication

Congenital deficiency in the WRN protein, a member of the human RecQ helicase family, gives rise to Werner syndrome, a genetic instability and cancer predisposition disorder with features of premature aging. Cellular roles of WRN are not fully elucidated. WRN has been implicated in telomere maintena...

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Bibliographic Details
Published in:DNA repair 2008-11, Vol.7 (11), p.1776-1786
Main Author: Sidorova, Julia M.
Format: Article
Language:English
Subjects:
Aging
Animals
Cell Cycle
Damage tolerance
DNA Repair
DNA Replication
Exodeoxyribonucleases - chemistry
Exodeoxyribonucleases - physiology
Human cell culture
Humans
Mice
Models, Biological
Models, Genetic
RecQ helicase
RecQ Helicases - chemistry
RecQ Helicases - physiology
Replication stress
S Phase
Telomere - ultrastructure
Werner syndrome
Werner Syndrome - genetics
Werner Syndrome Helicase
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Summary:Congenital deficiency in the WRN protein, a member of the human RecQ helicase family, gives rise to Werner syndrome, a genetic instability and cancer predisposition disorder with features of premature aging. Cellular roles of WRN are not fully elucidated. WRN has been implicated in telomere maintenance, homologous recombination, DNA repair, and other processes. Here I review the available data that directly address the role of WRN in preserving DNA integrity during replication and propose that WRN can function in coordinating replication fork progression with replication stress-induced fork remodeling. I further discuss this role of WRN within the contexts of damage tolerance group of regulatory pathways, and redundancy and cooperation with other RecQ helicases.
ISSN:1568-7864
1568-7856
DOI:10.1016/j.dnarep.2008.07.017