Psoriasis: advances in pathophysiology and management

Psoriasis is an inflammatory skin disease that affects 13 of Caucasian populations and may be persistent, disfiguring and stigmatising. There is a range of severity, but even when the affected body surface area is relatively limited the impact on day-to-day activities and social interactions may be...

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Bibliographic Details
Published in:Postgraduate medical journal 2007-11, Vol.83 (985), p.690-697
Main Authors: MacDonald, A, Burden, A D
Format: Article
Language:English
Subjects:
Administration, Oral
Administration, Topical
Alcohol
Atherosclerosis
biological
Biological and medical sciences
Cancer therapies
Cardiovascular disease
Dermatologic Agents - administration & dosage
Dermatology
Diabetes
General aspects
Genotype
Humans
Immunotherapy - methods
Lymphoma
Medical sciences
pathophysiology
Pharmaceutical industry
Prescription drugs
Psoriasis
Psoriasis - etiology
Psoriasis - therapy
Psoriasis. Parapsoriasis. Lichen
PUVA Therapy - methods
Quality of life
Review
Skin cancer
Steroids - administration & dosage
Transplants & implants
Tumor necrosis factor-TNF
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Summary:Psoriasis is an inflammatory skin disease that affects 13 of Caucasian populations and may be persistent, disfiguring and stigmatising. There is a range of severity, but even when the affected body surface area is relatively limited the impact on day-to-day activities and social interactions may be significant. An understanding of the psychological burden and an appreciation that many patients are currently dissatisfied with their management has driven the development of more effective treatment. In recent years psoriasis has been the focus of intense investigation resulting in an improved understanding of the immunopathogenesis, and the development of new, targeted biological treatments.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.2007.061473