Fabrication of Modified Release Tablet Formulation of Metoprolol Succinate using Hydroxypropyl Methylcellulose and Xanthan Gum

The present investigation was undertaken to fabricate modified release tablet of metoprolol succinate using hydroxypropyl methylcellulose (HPMC) and xanthan gum as a matrixing agent. A 3 2 full factorial design was employed for the optimization of formulation. The percentage drug released at a given...

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Bibliographic Details
Published in:AAPS PharmSciTech 2009, Vol.10 (1), p.62-68
Main Authors: Gohel, Mukesh C., Parikh, Rajesh K., Nagori, Stavan A., Jena, Dillip G.
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - chemistry
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Buffers
Chemistry, Pharmaceutical
Delayed-Action Preparations
Drug Carriers
Gels
Hydrogen-Ion Concentration
Hypromellose Derivatives
Kinetics
Methylcellulose - analogs & derivatives
Methylcellulose - chemistry
Metoprolol - analogs & derivatives
Metoprolol - chemistry
Models, Chemical
Pharmacology/Toxicology
Pharmacy
Polysaccharides, Bacterial - chemistry
Research Article
Solubility
Tablets
Technology, Pharmaceutical - methods
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Summary:The present investigation was undertaken to fabricate modified release tablet of metoprolol succinate using hydroxypropyl methylcellulose (HPMC) and xanthan gum as a matrixing agent. A 3 2 full factorial design was employed for the optimization of formulation. The percentage drug released at a given time ( Y 60 , Y 240 and Y 720 ) and the time required for a given percentage of drug to be released ( t 50% ) were selected as dependent variables. The in vitro drug dissolution study was carried out in pH 6.8 phosphate buffer employing paddle rotated at 50 rpm. The similarity factor ( f 2 ) was calculated for selection of best batch considering mean in vitro dissolution data of Seloken® XL as a reference profile. It is concluded that the desired drug release pattern can be obtained by using a proper combination of HPMC (high gelling ability) and xanthan gum (quick gelling tendency). The economy of xanthan gum and faster hydration rate favors its use in modified release tablets. The matrix integrity during dissolution testing was maintained by using hydroxypropyl methylcellulose.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-008-9174-1