Crystallization and preliminary X-ray diffraction analysis of human seminal plasma protein PSP94

The human seminal plasma protein PSP94 is a small protein of 94 residues that contains ten cysteines. Since its discovery about 25 years ago, several potential biological functions have been reported for this protein. Many PSP94 homologues have also been identified since then from various species, b...

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Bibliographic Details
Published in:Acta crystallographica. Section F, Structural biology and crystallization communications Structural biology and crystallization communications, 2009-04, Vol.65 (4), p.389-391
Main Authors: Kumar, Mukesh, Jagtap, Dhanashree D., Mahale, Smita D., Prashar, Vishal, Kumar, Ashwani, Das, Amit, Bihani, Subhash C., Ferrer, Jean-Luc, Hosur, Madhusoodan V., Ramanadham, M.
Format: Article
Language:English
Subjects:
Crystallization
Crystallization Communications
Crystallography, X-Ray
human seminal plasma protein
Humans
Prostatic Secretory Proteins - chemistry
PSP94
Seminal Plasma Proteins - chemistry
X-Ray Diffraction
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Summary:The human seminal plasma protein PSP94 is a small protein of 94 residues that contains ten cysteines. Since its discovery about 25 years ago, several potential biological functions have been reported for this protein. Many PSP94 homologues have also been identified since then from various species, but no crystal structure has been determined to date. PSP94 has been purified from human seminal plasma and crystallized. These crystals diffracted to ∼2.3 Å resolution and belonged to space group P41212, with unit‐cell parameters a = 107.9, b = 107.9, c = 92.1 Å. There are four molecules in the asymmetric unit. Structure solution by the heavy‐atom method is currently in progress.
ISSN:1744-3091
1744-3091
DOI:10.1107/S1744309109008549