Self-Assembly of Giant Peptide Nanobelts

• Published in: Nano letters 2009-03, Vol.9 (3), p.945-951
• Main Authors: Cui, Honggang, Muraoka, Takahiro, Cheetham, Andrew G, Stupp, Samuel I
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Biotechnology; Circular Dichroism; Condensed matter: structure, mechanical and thermal properties; Cross-disciplinary physics: materials science; rheology; Cryoelectron Microscopy - methods; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; Hydrogen-Ion Concentration; Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties; Macromolecular Substances; Materials science; Materials Testing; Methods of nanofabrication; Methods. Procedures. Technologies; Microscopy, Atomic Force; Microscopy, Electron, Transmission - methods; Models, Chemical; Nanocrystalline materials; Nanoscale materials and structures: fabrication and characterization; Nanostructures - chemistry; Nanotechnology - methods; Others; Peptides - chemistry; Physics; Self-assembly; Surface Properties; Surfaces and interfaces; thin films and whiskers (structure and nonelectronic properties); Various methods and equipments; Water - chemistry
• ISSN: 1530-6984; 1530-6992
• DOI: 10.1021/nl802813f

Many alkylated peptide amphiphiles have been reported to self-assemble into cylindrical nanofibers with diameters on the order of a few nanometers and micrometer scale lengths; these nanostructures can be highly bioactive and are of great interest in many biomedical applications. We have discovered the sequences for these molecules that can eliminate all curvature from the nanostructures they form in water and generate completely flat nanobelts with giant dimensions relative to previously reported systems. The nanobelts have fairly monodisperse widths on the order of 150 nm and lengths of up to 0.1 mm. The sequences have an alternating sequence with hydrophobic and hydrophilic side chains and variations in monomer concentration generate a “broom” morphology with twisted ribbons that reveals the mechanism through which giant nanobelts form. Interestingly, a variation in pH generates reversibly periodic 2 nm grooves on the surfaces of the nanobelts. With proper functionalization, these nanostructures offer a novel architecture to present epitopes to cells for therapeutic applications.