Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects

Brain-derived neurotrophic factor (BDNF) has been implicated in the mechanism of age-related regional brain volumetric changes. Healthy volunteers with the valine to methionine polymorphism at codon 66 of the BDNF gene (val66met) exhibit decreased volume of a number of brain structures, including hi...

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Published in:Progress in neuro-psychopharmacology & biological psychiatry 2008-10, Vol.32 (7), p.1652-1655
Main Authors: Sublette, M. Elizabeth, Baca-Garcia, Enrique, Parsey, Ramin V., Oquendo, Maria A., Rodrigues, Sarina M., Galfalvy, Hanga, Huang, Yung-Yu, Arango, Victoria, Mann, J. John
Format: Article
Language:English
Subjects:
Adult
Aging
Amygdala
Amygdala - anatomy & histology
Analysis of Variance
BDNF
Biological and medical sciences
Brain-Derived Neurotrophic Factor - genetics
Development. Senescence. Regeneration. Transplantation
Female
Fundamental and applied biological sciences. Psychology
Genotype
Humans
Magnetic Resonance Imaging - methods
Male
Methionine - genetics
Middle Aged
MRI
Polymorphism, Genetic - genetics
Regression Analysis
Valine - genetics
Vertebrates: nervous system and sense organs
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Summary:Brain-derived neurotrophic factor (BDNF) has been implicated in the mechanism of age-related regional brain volumetric changes. Healthy volunteers with the valine to methionine polymorphism at codon 66 of the BDNF gene (val66met) exhibit decreased volume of a number of brain structures, including hippocampus, temporal and occipital lobar gray matter volumes, and a negative correlation between age and the volume of bilateral dorsolateral prefrontal cortices. We sought to characterize the relationship between age, BDNF and amygdala volumes among healthy volunteers. We measured amygdala volumes in 55 healthy, right-handed volunteers who underwent structural magnetic resonance imaging (MRI) and were also characterized demographically and genotyped with respect to BDNF. Using an ANCOVA model, we found that amygdala volumes were inversely correlated with age in BDNF val66met carriers but not in non-carriers. This is the first report of age-related BDNF val66met polymorphism effects on amygdala volume.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2008.06.009