Mast cells as regulators of adaptive immunity to tumours

The observation that mast cells accumulate at the periphery of growing tumours is now well documented, and the loss of mast cells correlates with reduced tumour growth. The role of mast cells as innate regulators of both inflammatory and immunosuppressive responses slowly becomes clear as novel tool...

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Bibliographic Details
Published in:Clinical and experimental immunology 2009-02, Vol.155 (2), p.140-146
Main Authors: Wasiuk, A, de Vries, V.C, Hartmann, K, Roers, A, Noelle, R.J
Format: Article
Language:English
Subjects:
acquired immunity
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Cell Communication - immunology
Dendritic Cells - immunology
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Humans
Immune Tolerance
immunity
immunosuppression
Lymphocyte Activation - immunology
mast cells
Mast Cells - immunology
Mice
Neoplasms - immunology
Review
T-Lymphocyte Subsets - immunology
Tumor Escape - immunology
tumour
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Summary:The observation that mast cells accumulate at the periphery of growing tumours is now well documented, and the loss of mast cells correlates with reduced tumour growth. The role of mast cells as innate regulators of both inflammatory and immunosuppressive responses slowly becomes clear as novel tools become available. This review will address the role of mast cells in tumours and how they can interact with the local immune environment to mediate immune suppression contributing to tumour escape.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2008.03840.x