Transporting newborn infants with suspected duct dependent congenital heart disease on low-dose prostaglandin E1 without routine mechanical ventilation

Aim: To evaluate the safety of transporting newborn infants with suspected duct dependent congenital heart disease (CHD) treated with prostaglandin E1 (PGE1) without routine mechanical ventilation. Methods: A retrospective population-based audit of newborn infants with suspected CHD transported on P...

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Bibliographic Details
Published in:Archives of disease in childhood. Fetal and neonatal edition 2007-03, Vol.92 (2), p.F117-F119
Main Authors: Browning Carmo, Kathryn A, Barr, Peter, West, Maureen, Hopper, Neil W, White, Jennifer P, Badawi, Nadia
Format: Article
Language:English
Subjects:
Alprostadil - administration & dosage
Alprostadil - adverse effects
Alprostadil - therapeutic use
Cardiovascular diseases
CHD
Congenital diseases
congenital heart disease
Drug Administration Schedule
Heart Defects, Congenital - drug therapy
Humans
Infant, Newborn
Infants
New South Wales
Newborn babies
Original
Perinatal Care - methods
PGE1
prostaglandin E1
Respiration, Artificial
Respiratory therapy
Retrospective Studies
Transportation of Patients - methods
Ventilation
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Summary:Aim: To evaluate the safety of transporting newborn infants with suspected duct dependent congenital heart disease (CHD) treated with prostaglandin E1 (PGE1) without routine mechanical ventilation. Methods: A retrospective population-based audit of newborn infants with suspected CHD transported on PGE1 by the New South Wales newborn and paediatric Transport Service from 1995 through 2005. Results: Mechanical ventilation was not used prior to treatment with PGE1 in 94 (31%) of the 300 infants. The indications for mechanical ventilation in the remaining 206 infants (69%) included elective mechanical ventilation because of the intention to use PGE1 (n  =  125) and severe hypoxaemia, acidosis or cardiorespiratory failure prior to commencing PGE1 (n  =  81). 16 (17%) of the 94 infants who were not ventilated initially required mechanical ventilation before transport because of apnoea, which developed within one hour of commencing PGE1. 2 (2.6%) of the 78 infants transported without mechanical ventilation developed apnoea in transit and both were receiving ⩾15 ng/kg/min of PGE1. Apnoea was more likely to occur in non-ventilated infants when the PGE1 infusion rate was ⩾15 ng/kg/min compared with
ISSN:1359-2998
1468-2052
DOI:10.1136/adc.2006.096305