Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics

Molecular imaging is a novel tool that has allowed non-invasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of biological processes at the cellular level. This technique has been confined to the field of nuclear ima...

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Bibliographic Details
Published in:International journal of nanomedicine 2007-01, Vol.2 (4), p.515-526
Main Authors: Tran, Trung D, Caruthers, Shelton D, Hughes, Michael, Marsh, John N, Cyrus, Tillmann, Winter, Patrick M, Neubauer, Anne M, Wickline, Samuel A, Lanza, Gregory M
Format: Article
Language:English
Subjects:
Clinical Medicine - trends
Contrast Media
Diagnostic Imaging - trends
Drug Carriers - chemistry
Drug Delivery Systems - trends
Fluorocarbons - chemistry
Molecular Probe Techniques - trends
Nanomedicine - trends
Nanoparticles
Nanoparticles - therapeutic use
Nanotechnology
Perfluorocarbons
Review
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Summary:Molecular imaging is a novel tool that has allowed non-invasive diagnostic imaging to transition from gross anatomical description to identification of specific tissue epitopes and observation of biological processes at the cellular level. This technique has been confined to the field of nuclear imaging; however, recent advances in nanotechnology have extended this research to include ultrasound (US) and magnetic resonance (MR) imaging. The exploitation of nanotechnology for MR and US molecular imaging has generated several candidate contrast agents. One multimodality platform, targeted perfluorocarbon (PFC) nanoparticles, is useful for noninvasive detection with US and MR, targeted drug delivery, and quantification.
ISSN:1176-9114
1178-2013