Silk Fibroin Microfluidic Devices

Microfluidic devices were fabricated from silk fibroin using an aqueous molding process adapted from soft lithography. The process results in mechanically robust, patent devices with macroscopic fluidic connections. Hepatocytes were seeded in the device and perfused for up to five days during which...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2007-10, Vol.19 (19), p.2847-2850
Main Authors: Bettinger, C. J., Cyr, K. M., Matsumoto, A., Langer, R., Borenstein, J. T., Kaplan, D. L.
Format: Article
Language:English
Subjects:
Biopolymers
Biosensors
Microelectromechanical systems
Microfluidic systems
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Summary:Microfluidic devices were fabricated from silk fibroin using an aqueous molding process adapted from soft lithography. The process results in mechanically robust, patent devices with macroscopic fluidic connections. Hepatocytes were seeded in the device and perfused for up to five days during which they exhibited liver‐specific functions equivalent to that observed for standard tissue culture substrates.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200602487