The chemokine system in arteriogenesis and hind limb ischemia

Chemokines (chemotactic cytokines) are important in the recruitment of leukocytes to injured tissues and, as such, play a pivotal role in arteriogenesis and the tissue response to ischemia. Hind limb ischemia represents a complex model with arteriogenesis (collateral artery formation) occurring in t...

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Bibliographic Details
Published in:Journal of vascular surgery 2007-06, Vol.45 (6), p.A48-A56
Main Author: Shireman, Paula K., MD
Format: Article
Language:English
Subjects:
Animals
Arteries - metabolism
Arteries - physiopathology
Chemokine CCL2 - metabolism
Chemokines - metabolism
Chemokines, CX3C - metabolism
Disease Models, Animal
Hindlimb
Inflammation - metabolism
Inflammation - physiopathology
Ischemia - metabolism
Ischemia - physiopathology
Macrophages - metabolism
Mice
Monocytes - metabolism
Muscle, Skeletal - blood supply
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiopathology
Neovascularization, Physiologic
Receptors, Chemokine - metabolism
Regeneration
Signal Transduction
Surgery
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Summary:Chemokines (chemotactic cytokines) are important in the recruitment of leukocytes to injured tissues and, as such, play a pivotal role in arteriogenesis and the tissue response to ischemia. Hind limb ischemia represents a complex model with arteriogenesis (collateral artery formation) occurring in tissues with normal perfusion while areas exhibiting ischemic necrosis undergo angiogenesis and skeletal muscle regeneration; monocytes and macrophages play an important role in all three of these processes. In addition to leukocyte trafficking, chemokines are produced by and chemokine receptors are present on diverse cell types, including myoblasts, endothelial, and smooth muscle cells. Thus, the chemokine system may have direct effects as well as inflammatory-mediated effects on arteriogenesis, angiogenesis, and skeletal muscle regeneration. This article reviews the complexity of the hind limb ischemia model and the role of the chemokine system in arteriogenesis and the tissue response to ischemia. Special emphasis will be placed on the roles of monocytes/macrophages and CCL2/monocyte chemotactic protein-1 (MCP-1) in these processes.
ISSN:0741-5214
1097-6809
DOI:10.1016/j.jvs.2007.02.030