A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study

• Published in: European heart journal 2009-05, Vol.30 (10), p.1222-1228
• Main Authors: Yamagishi, Kazumasa, Folsom, Aaron R., Rosamond, Wayne D., Boerwinkle, Eric
• Format: Article
• Language: English
• Subjects: African Americans - genetics; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - genetics; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Carotid Artery Diseases - epidemiology; Carotid Artery Diseases - genetics; Chromosomes, Human, Pair 9 - genetics; Clinical Research; Cohort study; Congestive heart failure; Epidemiologic Methods; Epidemiology; European Continental Ancestry Group - genetics; Female; Genetic Predisposition to Disease; Genetics; Genotype; Heart; Heart Failure - epidemiology; Heart Failure - genetics; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Homozygote; Humans; Male; Medical sciences; Middle Aged; Peripheral Vascular Diseases - epidemiology; Peripheral Vascular Diseases - genetics; Polymorphism, Single Nucleotide; Stroke - epidemiology; Stroke - genetics
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehp087

Aims Recent studies showed that polymorphisms on chromosome 9p21 are associated with coronary heart disease (CHD), but few studies examined the association with heart failure (HF), stroke, or other subclinical atherosclerotic diseases. We tested the association of chromosome 9p21 polymorphisms with non-coronary atherosclerotic diseases. Methods and results We studied 4018 African-American and 11 085 white participants from the Atherosclerosis Risk in Communities Study, aged 45–64 at baseline (1987–89). We examined associations of rs10757274 and rs2383206 polymorphisms with incident HF through 2005 and ischaemic stroke through 2004, and with prevalent carotid atherosclerosis and peripheral artery disease (PAD) at baseline. The GG genotype of rs10757274 was associated with increased HF risk for whites. This association seemed independent of the established link between rs10757274 and clinical CHD, although an impact of rs10757274 on subclinical CHD leading to HF is not eliminated. Among whites, GG homozygotes were at weakly increased carotid atherosclerosis risk. There seemed to be no associations for ischaemic stroke or PAD. The results were essentially similar for rs2383206. Conclusion The GG genotype of rs10757274 on chromosome 9p21, which has been shown to increase CHD risk, is also associated with increased HF risk among whites. It is weakly or not associated with several other atherosclerosis outcomes.