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Adipokines, Inflammation, and Visceral Adiposity across the Menopausal Transition: A Prospective Study
Context: Postmenopausal women have greater visceral adiposity compared with premenopausal women. Adipokines are associated with increased adiposity, insulin resistance, and atherosclerosis. Objective: The objective of the study was to assess changes in adipokines and inflammatory markers through the...
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Published in: | The journal of clinical endocrinology and metabolism 2009-04, Vol.94 (4), p.1104-1110 |
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description | Context: Postmenopausal women have greater visceral adiposity compared with premenopausal women. Adipokines are associated with increased adiposity, insulin resistance, and atherosclerosis.
Objective: The objective of the study was to assess changes in adipokines and inflammatory markers through the menopausal transition and correlate them with changes in visceral adiposity.
Design and Setting: This was a prospective cohort study of women through the menopausal transition conducted at the University of Washington.
Participants: Sixty-nine healthy women were followed up longitudinally from premenopausal (aged 45–55 yr) to postmenopausal status (aged 49–60 yr).
Outcome: On premenopausal and postmenopausal visits, fasting blood was drawn for adiponectin, leptin, serum amyloid A (SAA), C-reactive protein (CRP), monocyte-chemotactic protein-1, tissue plasminogen activator antigen (tPA), IL-6, and TNF-α. Body composition measures were assessed by body mass index, whole-body dual x-ray absorptiometry scan, and computed tomography scan of the abdomen at the lumbar 4–5 level.
Results: Women had a statistically significant increase in SAA, tPA, monocyte-chemotactic protein-1, and adiponectin between the two measurement occasions (P = 0.04, P = 0.02, P = 0.001, and P < 0.001, respectively). The increase in intraabdominal fat was correlated positively with the change in SAA (r = 0.31, P = 0.02), CRP (r = 0.56, P < 0.001), tPA (r = 0.40, P = 0.002), and leptin (r = 0.41, P = 0.002) and negatively correlated with the change in adiponectin (r = −0.37, P = 0.005). After adjustment for change in sc abdominal fat, the correlation between change in CRP, tPA, leptin, and adiponectin remained significantly associated with change in intraabdominal fat.
Conclusions: Women going through the menopausal transition have deleterious changes in inflammatory markers and adipokines that correlate with increased visceral adiposity.
During the menopausal transition, women develop adverse alterations in adipokines and inflammatory markers in relation to increasing visceral adiposity. |
doi_str_mv | 10.1210/jc.2008-0701 |
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Objective: The objective of the study was to assess changes in adipokines and inflammatory markers through the menopausal transition and correlate them with changes in visceral adiposity.
Design and Setting: This was a prospective cohort study of women through the menopausal transition conducted at the University of Washington.
Participants: Sixty-nine healthy women were followed up longitudinally from premenopausal (aged 45–55 yr) to postmenopausal status (aged 49–60 yr).
Outcome: On premenopausal and postmenopausal visits, fasting blood was drawn for adiponectin, leptin, serum amyloid A (SAA), C-reactive protein (CRP), monocyte-chemotactic protein-1, tissue plasminogen activator antigen (tPA), IL-6, and TNF-α. Body composition measures were assessed by body mass index, whole-body dual x-ray absorptiometry scan, and computed tomography scan of the abdomen at the lumbar 4–5 level.
Results: Women had a statistically significant increase in SAA, tPA, monocyte-chemotactic protein-1, and adiponectin between the two measurement occasions (P = 0.04, P = 0.02, P = 0.001, and P < 0.001, respectively). The increase in intraabdominal fat was correlated positively with the change in SAA (r = 0.31, P = 0.02), CRP (r = 0.56, P < 0.001), tPA (r = 0.40, P = 0.002), and leptin (r = 0.41, P = 0.002) and negatively correlated with the change in adiponectin (r = −0.37, P = 0.005). After adjustment for change in sc abdominal fat, the correlation between change in CRP, tPA, leptin, and adiponectin remained significantly associated with change in intraabdominal fat.
Conclusions: Women going through the menopausal transition have deleterious changes in inflammatory markers and adipokines that correlate with increased visceral adiposity.
During the menopausal transition, women develop adverse alterations in adipokines and inflammatory markers in relation to increasing visceral adiposity.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2008-0701</identifier><identifier>PMID: 19126626</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Abdomen ; Adipokines - blood ; Adiponectin - blood ; Adipose Tissue - anatomy & histology ; Adult ; Biological and medical sciences ; Body Composition - physiology ; C-Reactive Protein - metabolism ; Cohort Studies ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Inflammation - physiopathology ; Leptin - blood ; Medical sciences ; Menopause - physiology ; Middle Aged ; Original ; Postmenopause - physiology ; Premenopause - physiology ; Prospective Studies ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Viscera</subject><ispartof>The journal of clinical endocrinology and metabolism, 2009-04, Vol.94 (4), p.1104-1110</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009 by The Endocrine Society 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-9afff88ebd8bda08f28b3629c3e935b5bce0d838d2d27eb07cd619cc590529e33</citedby><cites>FETCH-LOGICAL-c522t-9afff88ebd8bda08f28b3629c3e935b5bce0d838d2d27eb07cd619cc590529e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21353952$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19126626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Christine G.</creatorcontrib><creatorcontrib>Carr, Molly C.</creatorcontrib><creatorcontrib>Murdoch, Susan J.</creatorcontrib><creatorcontrib>Mitchell, Ellen</creatorcontrib><creatorcontrib>Woods, Nancy F.</creatorcontrib><creatorcontrib>Wener, Mark H.</creatorcontrib><creatorcontrib>Chandler, Wayne L.</creatorcontrib><creatorcontrib>Boyko, Edward J.</creatorcontrib><creatorcontrib>Brunzell, John D.</creatorcontrib><title>Adipokines, Inflammation, and Visceral Adiposity across the Menopausal Transition: A Prospective Study</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context: Postmenopausal women have greater visceral adiposity compared with premenopausal women. Adipokines are associated with increased adiposity, insulin resistance, and atherosclerosis.
Objective: The objective of the study was to assess changes in adipokines and inflammatory markers through the menopausal transition and correlate them with changes in visceral adiposity.
Design and Setting: This was a prospective cohort study of women through the menopausal transition conducted at the University of Washington.
Participants: Sixty-nine healthy women were followed up longitudinally from premenopausal (aged 45–55 yr) to postmenopausal status (aged 49–60 yr).
Outcome: On premenopausal and postmenopausal visits, fasting blood was drawn for adiponectin, leptin, serum amyloid A (SAA), C-reactive protein (CRP), monocyte-chemotactic protein-1, tissue plasminogen activator antigen (tPA), IL-6, and TNF-α. Body composition measures were assessed by body mass index, whole-body dual x-ray absorptiometry scan, and computed tomography scan of the abdomen at the lumbar 4–5 level.
Results: Women had a statistically significant increase in SAA, tPA, monocyte-chemotactic protein-1, and adiponectin between the two measurement occasions (P = 0.04, P = 0.02, P = 0.001, and P < 0.001, respectively). The increase in intraabdominal fat was correlated positively with the change in SAA (r = 0.31, P = 0.02), CRP (r = 0.56, P < 0.001), tPA (r = 0.40, P = 0.002), and leptin (r = 0.41, P = 0.002) and negatively correlated with the change in adiponectin (r = −0.37, P = 0.005). After adjustment for change in sc abdominal fat, the correlation between change in CRP, tPA, leptin, and adiponectin remained significantly associated with change in intraabdominal fat.
Conclusions: Women going through the menopausal transition have deleterious changes in inflammatory markers and adipokines that correlate with increased visceral adiposity.
During the menopausal transition, women develop adverse alterations in adipokines and inflammatory markers in relation to increasing visceral adiposity.</description><subject>Abdomen</subject><subject>Adipokines - blood</subject><subject>Adiponectin - blood</subject><subject>Adipose Tissue - anatomy & histology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Composition - physiology</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cohort Studies</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inflammation - physiopathology</subject><subject>Leptin - blood</subject><subject>Medical sciences</subject><subject>Menopause - physiology</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Postmenopause - physiology</subject><subject>Premenopause - physiology</subject><subject>Prospective Studies</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><subject>Viscera</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNptkctv1DAYxC0EokvLjTPyBU6b4kceNodKq4pHpSKQ-hA3y7G_UC-JHeyk0v73ON1VAYmTD_PzfKMZhF5RckoZJe-25pQRIgrSEPoEragsq6KhsnmKVoQwWsiGfT9CL1LaEkLLsuLP0RGVlNU1q1eo21g3hp_OQ1rjC9_1ehj05IJfY-0tvnXJQNQ9fsCSm3ZYmxhSwtMd4C_gw6jnlPXrqH2W88f3eIO_ZWQEM7l7wFfTbHcn6Fmn-wQvD-8xuvn44fr8c3H59dPF-eayMBVjUyF113VCQGtFazURHRMtr5k0HCSv2qo1QKzgwjLLGmhJY2xNpTGVJBWTwPkxOtv7jnM7gDXgp5xejdENOu5U0E79q3h3p36Ee8VqwcqaZYO3B4MYfs2QJjUsFfS99hDmpOqGsqbkIoPrPfhQR4Tu8QglahlGbY1ahlHLMBl__XewP_BhiQy8OQA6Gd13uU_j0iPHKK-4rJaAfM-Bt8HEPNwYISW1DXP0udr_n_8NIC6p8w</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Lee, Christine G.</creator><creator>Carr, Molly C.</creator><creator>Murdoch, Susan J.</creator><creator>Mitchell, Ellen</creator><creator>Woods, Nancy F.</creator><creator>Wener, Mark H.</creator><creator>Chandler, Wayne L.</creator><creator>Boyko, Edward J.</creator><creator>Brunzell, John D.</creator><general>Endocrine Society</general><general>The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090401</creationdate><title>Adipokines, Inflammation, and Visceral Adiposity across the Menopausal Transition: A Prospective Study</title><author>Lee, Christine G. ; Carr, Molly C. ; Murdoch, Susan J. ; Mitchell, Ellen ; Woods, Nancy F. ; Wener, Mark H. ; Chandler, Wayne L. ; Boyko, Edward J. ; Brunzell, John D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-9afff88ebd8bda08f28b3629c3e935b5bce0d838d2d27eb07cd619cc590529e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Abdomen</topic><topic>Adipokines - blood</topic><topic>Adiponectin - blood</topic><topic>Adipose Tissue - anatomy & histology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Composition - physiology</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cohort Studies</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inflammation - physiopathology</topic><topic>Leptin - blood</topic><topic>Medical sciences</topic><topic>Menopause - physiology</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Postmenopause - physiology</topic><topic>Premenopause - physiology</topic><topic>Prospective Studies</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><topic>Viscera</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Christine G.</creatorcontrib><creatorcontrib>Carr, Molly C.</creatorcontrib><creatorcontrib>Murdoch, Susan J.</creatorcontrib><creatorcontrib>Mitchell, Ellen</creatorcontrib><creatorcontrib>Woods, Nancy F.</creatorcontrib><creatorcontrib>Wener, Mark H.</creatorcontrib><creatorcontrib>Chandler, Wayne L.</creatorcontrib><creatorcontrib>Boyko, Edward J.</creatorcontrib><creatorcontrib>Brunzell, John D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Christine G.</au><au>Carr, Molly C.</au><au>Murdoch, Susan J.</au><au>Mitchell, Ellen</au><au>Woods, Nancy F.</au><au>Wener, Mark H.</au><au>Chandler, Wayne L.</au><au>Boyko, Edward J.</au><au>Brunzell, John D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adipokines, Inflammation, and Visceral Adiposity across the Menopausal Transition: A Prospective Study</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>94</volume><issue>4</issue><spage>1104</spage><epage>1110</epage><pages>1104-1110</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context: Postmenopausal women have greater visceral adiposity compared with premenopausal women. Adipokines are associated with increased adiposity, insulin resistance, and atherosclerosis.
Objective: The objective of the study was to assess changes in adipokines and inflammatory markers through the menopausal transition and correlate them with changes in visceral adiposity.
Design and Setting: This was a prospective cohort study of women through the menopausal transition conducted at the University of Washington.
Participants: Sixty-nine healthy women were followed up longitudinally from premenopausal (aged 45–55 yr) to postmenopausal status (aged 49–60 yr).
Outcome: On premenopausal and postmenopausal visits, fasting blood was drawn for adiponectin, leptin, serum amyloid A (SAA), C-reactive protein (CRP), monocyte-chemotactic protein-1, tissue plasminogen activator antigen (tPA), IL-6, and TNF-α. Body composition measures were assessed by body mass index, whole-body dual x-ray absorptiometry scan, and computed tomography scan of the abdomen at the lumbar 4–5 level.
Results: Women had a statistically significant increase in SAA, tPA, monocyte-chemotactic protein-1, and adiponectin between the two measurement occasions (P = 0.04, P = 0.02, P = 0.001, and P < 0.001, respectively). The increase in intraabdominal fat was correlated positively with the change in SAA (r = 0.31, P = 0.02), CRP (r = 0.56, P < 0.001), tPA (r = 0.40, P = 0.002), and leptin (r = 0.41, P = 0.002) and negatively correlated with the change in adiponectin (r = −0.37, P = 0.005). After adjustment for change in sc abdominal fat, the correlation between change in CRP, tPA, leptin, and adiponectin remained significantly associated with change in intraabdominal fat.
Conclusions: Women going through the menopausal transition have deleterious changes in inflammatory markers and adipokines that correlate with increased visceral adiposity.
During the menopausal transition, women develop adverse alterations in adipokines and inflammatory markers in relation to increasing visceral adiposity.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>19126626</pmid><doi>10.1210/jc.2008-0701</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Abdomen Adipokines - blood Adiponectin - blood Adipose Tissue - anatomy & histology Adult Biological and medical sciences Body Composition - physiology C-Reactive Protein - metabolism Cohort Studies Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Inflammation - physiopathology Leptin - blood Medical sciences Menopause - physiology Middle Aged Original Postmenopause - physiology Premenopause - physiology Prospective Studies Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Viscera |
title | Adipokines, Inflammation, and Visceral Adiposity across the Menopausal Transition: A Prospective Study |
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