Analysis of the gene coding for the BRCA2-Interacting protein PALB2 in hereditary prostate cancer

BACKGROUND The genetic basis of susceptibility to prostate cancer (PRCA) remains elusive. Mutations in BRCA2 have been associated with increased prostate cancer risk and account for around 2% of young onset (

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Bibliographic Details
Published in:The Prostate 2008-05, Vol.68 (6), p.675-678
Main Authors: Tischkowitz, Marc, Sabbaghian, Nelly, Ray, Anna M., Lange, Ethan M., Foulkes, William D., Cooney, Kathleen A.
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - genetics
Adenocarcinoma - surgery
Adult
Biological and medical sciences
BRCA2
Fanconi Anemia Complementation Group N Protein
Fathers
Genetic Predisposition to Disease
Genetic Testing
Gynecology. Andrology. Obstetrics
hereditary prostate cancer
Humans
Male
Male genital diseases
Medical sciences
Middle Aged
Mutation
Nephrology. Urinary tract diseases
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
PALB2
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - genetics
Prostatic Neoplasms - surgery
Sequence Analysis, DNA
Siblings
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
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Description
Summary:BACKGROUND The genetic basis of susceptibility to prostate cancer (PRCA) remains elusive. Mutations in BRCA2 have been associated with increased prostate cancer risk and account for around 2% of young onset (
ISSN:0270-4137
1097-0045
DOI:10.1002/pros.20729