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Targeting Protein Serine/Threonine Phosphatases for Drug Development

With the recent clinical success of drugs targeting protein kinase activity, drug discovery efforts are focusing on the role of reversible protein phosphorylation in disease states. The activity of protein phosphatases, enzymes that oppose protein kinases, can also be manipulated to alter cellular s...

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Bibliographic Details
Published in:Molecular pharmacology 2009-06, Vol.75 (6), p.1249-1261
Main Authors: McConnell, Jamie L., Wadzinski, Brian E.
Format: Article
Language:English
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Summary:With the recent clinical success of drugs targeting protein kinase activity, drug discovery efforts are focusing on the role of reversible protein phosphorylation in disease states. The activity of protein phosphatases, enzymes that oppose protein kinases, can also be manipulated to alter cellular signaling for therapeutic benefits. In this review, we present protein serine/threonine phosphatases as viable therapeutic targets, discussing past successes, current challenges, and future strategies for modulating phosphatase activity.
ISSN:0026-895X
1521-0111
DOI:10.1124/mol.108.053140