STRING 8—a global view on proteins and their functional interactions in 630 organisms

Functional partnerships between proteins are at the core of complex cellular phenotypes, and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling, data reduction and annotation. STRING is a database and web resource dedicated to protein–protein interact...

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Bibliographic Details
Published in:Nucleic acids research 2009-01, Vol.37 (suppl-1), p.D412-D416
Main Authors: Jensen, Lars J., Kuhn, Michael, Stark, Manuel, Chaffron, Samuel, Creevey, Chris, Muller, Jean, Doerks, Tobias, Julien, Philippe, Roth, Alexander, Simonovic, Milan, Bork, Peer, von Mering, Christian
Format: Article
Language:English
Subjects:
Biochemistry, Molecular Biology
Bioinformatics
Computer Science
Databases, Protein
Genomics
Life Sciences
Multiprotein Complexes - metabolism
Protein Interaction Mapping
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
User-Computer Interface
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Summary:Functional partnerships between proteins are at the core of complex cellular phenotypes, and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling, data reduction and annotation. STRING is a database and web resource dedicated to protein–protein interactions, including both physical and functional interactions. It weights and integrates information from numerous sources, including experimental repositories, computational prediction methods and public text collections, thus acting as a meta-database that maps all interaction evidence onto a common set of genomes and proteins. The most important new developments in STRING 8 over previous releases include a URL-based programming interface, which can be used to query STRING from other resources, improved interaction prediction via genomic neighborhood in prokaryotes, and the inclusion of protein structures. Version 8.0 of STRING covers about 2.5 million proteins from 630 organisms, providing the most comprehensive view on protein–protein interactions currently available. STRING can be reached at http://string-db.org/.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkn760