The inextricable link between atherosclerosis and prototypical inflammatory diseases rheumatoid arthritis and systemic lupus erythematosus

The increased burden of cardiovascular disease in patients with rheumatoid arthritis and systemic lupus erythematosus has recently become the focus of intense investigation. Proatherogenic risk factors and dysregulated inflammation are the main culprits, leading to enhanced atherosclerosis in subgro...

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Bibliographic Details
Published in:Arthritis research & therapy 2009-01, Vol.11 (2), p.217-217
Main Authors: FULL, Louise E, RUISANCHEZ, Cristina, MONACO, Claudia
Format: Article
Language:English
Subjects:
Animals
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - physiopathology
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - complications
Atherosclerosis - immunology
Atherosclerosis - physiopathology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Diseases of the osteoarticular system
Humans
Inflammatory joint diseases
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - physiopathology
Medical sciences
Review
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:The increased burden of cardiovascular disease in patients with rheumatoid arthritis and systemic lupus erythematosus has recently become the focus of intense investigation. Proatherogenic risk factors and dysregulated inflammation are the main culprits, leading to enhanced atherosclerosis in subgroups of patients with inflammatory diseases. Common molecular pathways shared by atherosclerosis and inflammatory disease may be involved. In this review we map the key determinants of the increased incidence of cardiovascular disease in patients with inflammatory diseases at each step of the atherogenesis.
ISSN:1478-6354
1478-6362
DOI:10.1186/ar2631