Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins

A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by diso...

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Bibliographic Details
Published in:Journal of biology (London, England) England), 2009, Vol.8 (3), p.27-27
Main Authors: Chan, Hue Sun, Zhang, Zhuqing
Format: Article
Language:English
Subjects:
Animals
Humans
Minireview
Models, Chemical
Mutation
Protein Binding
Protein Conformation
Protein Folding
Proteins - chemistry
Proteins - metabolism
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Summary:A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by disordered conformational ensembles in protein behavior.
ISSN:1475-4924
1478-5854
1475-4924
DOI:10.1186/jbiol126