Microemulsion-Based Vaginal Gel of Clotrimazole: Formulation, In Vitro Evaluation, and Stability Studies

The objective of the present investigation was to develop and evaluate microemulsion-based gel for the vaginal delivery of clotrimazole (CMZ). The solubility of CMZ in oils and surfactants was evaluated to identify components of the microemulsion. The ternary diagram was plotted to identify the area...

Full description

Saved in:
Bibliographic Details
Published in:AAPS PharmSciTech 2009-06, Vol.10 (2), p.476-481, Article 476
Main Authors: Bachhav, Yogeshwar G., Patravale, Vandana B.
Format: Article
Language:English
Subjects:
Acrylic Resins
Antifungal Agents - administration & dosage
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Chemistry, Pharmaceutical
Clotrimazole - administration & dosage
Clotrimazole - chemistry
Clotrimazole - pharmacology
Drug Stability
Emulsions
Microbial Sensitivity Tests
Pharmacology/Toxicology
Pharmacy
Polyvinyls - administration & dosage
Research Article
Solubility
Vaginal Creams, Foams, and Jellies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of the present investigation was to develop and evaluate microemulsion-based gel for the vaginal delivery of clotrimazole (CMZ). The solubility of CMZ in oils and surfactants was evaluated to identify components of the microemulsion. The ternary diagram was plotted to identify the area of microemulsion existence. Various gelling agents were evaluated for their potential to gel the CMZ microemulsion without affecting its structure. The bioadhesive potential and antifungal activity of the CMZ microemulsion-based gel (CMZ-MBG) was determined in comparison to the marketed clotrimazole gel (Candid-V® gel) by in vitro methods. The chemical stability of CMZ in CMZ-MBG was determined as per the International Conference on Harmonization guidelines. The CMZ microemulsion exhibited globule size of 48.4 nm and polydispersity index of 0.75. Carbopol® ETD 2020 could successfully gel the CMZ microemulsion without disturbing the structure. The CMZ-MBG showed significantly higher ( P  
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-009-9233-2