Effect of defective connective tissue on the formation of aneurysmal-like structures in the rat testicular artery

Microscopic aneurysmal‐like structures (ALS) develop spontaneously in the convoluted rat testicular artery and have been previously proposed as a model relevant to cerebral aneurysms. The effect of defects in connective tissue fibres on ALS formation was investigated by microscopy using two approach...

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Bibliographic Details
Published in:International journal of experimental pathology 1996-04, Vol.77 (2), p.53-62
Main Authors: COUTARD, MICHÈLE, OSBORNE-PELLEGRIN, MARY
Format: Article
Language:English
Subjects:
Aminopropionitrile - toxicity
aneurysm
Aneurysm - chemically induced
Aneurysm - etiology
Aneurysm - pathology
Animals
Arteries - ultrastructure
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
connective tissue
Connective Tissue Diseases - complications
Male
Medical sciences
Microscopy, Electron
Miscellaneous
Original
rat testicular artery
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Testis - blood supply
Testis - ultrastructure
Tunica Intima - ultrastructure
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Summary:Microscopic aneurysmal‐like structures (ALS) develop spontaneously in the convoluted rat testicular artery and have been previously proposed as a model relevant to cerebral aneurysms. The effect of defects in connective tissue fibres on ALS formation was investigated by microscopy using two approaches: (i) the study of the effect of β‐aminopropionitrile (BAPN), an inhibitor of the cross‐linking of elastic and collagen fibres, on the incidence, size and morphology of ALS in spontaneously hypertensive rats (SHR) and their normotensive controls (WKY). The straight spermatic artery was studied for comparison. (ii) The determination of the incidence of spontaneous ALS in Brown Norway (BN) and Long Evans (LE) rats which are highly susceptible (BN) or resistant (LE) to the spontaneous rupture of the arterial internal elastic lamina. (i) BAPN increased the number and size of ALS in SHR and WKY rats and had no effect on the straight spermatic artery and (ii) ALS were more numerous and of greater size in BN than in LE rats. Taken together, these results show that defective connective tissue fibres may favour the formation and induce the enlargement of aneurysmal‐like structures. By analogy, these data suggest that a lack of connective tissue fibre integrity may be of importance in cerebral aneurysm formation and development.
ISSN:0959-9673
1365-2613
DOI:10.1046/j.1365-2613.1996.00963.x