Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and activation of systemic immunity with the capacity to exacerbate neuropathology and stimulate mechanisms of tissue repair. Despite our incomplete understanding of the mechanisms that control these divergent function...

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Bibliographic Details
Published in:Experimental neurology 2008-02, Vol.209 (2), p.378-388
Main Authors: Donnelly, Dustin J., Popovich, Phillip G.
Format: Article
Language:English
Subjects:
Animals
Axons - physiology
Blood–brain barrier
Humans
Inflammation - physiopathology
Lymphocytes
Macrophages
Neuroinflammation
Recovery of Function - physiology
Regeneration - physiology
Spinal Cord Injuries - metabolism
Spinal Cord Injuries - pathology
Spinal Cord Injuries - physiopathology
Spinal cord injury
Traumatic brain injury
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Summary:Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and activation of systemic immunity with the capacity to exacerbate neuropathology and stimulate mechanisms of tissue repair. Despite our incomplete understanding of the mechanisms that control these divergent functions, immune-based therapies are becoming a therapeutic focus. This review will address the complexities and controversies of post-traumatic neuroinflammation, particularly in spinal cord. In addition, current therapies designed to target neuroinflammatory cascades will be discussed.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2007.06.009