Helicobacter pylori cagA gene variants in Malaysians of different ethnicity

We have defined DNA repeat variability in the 3'-terminus of the cagA gene of Helicobacter pylori strains from Malaysian patients of different ethnicities. We identified different alleles based on the EPIYA repeats. cagA types A-B-D and A-B-B-D are more similar to the sequence of Japanese strai...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2009-07, Vol.28 (7), p.865-869
Main Authors: Mohamed, Ramelah, Hanafiah, Alfizah, Rose, Isa M, Manaf, Mohd Rizal A, Abdullah, Shiekh Anwar, Sagap, Ismail, van Belkum, A, Yaacob, Jasmi A
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigens, Bacterial - genetics
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial Proteins - genetics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Biopsy
Brief Report
Continental Population Groups
Disease
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Endoscopy
Ethnicity
Gastroesophageal reflux
Genotypes
Helicobacter Infections - epidemiology
Helicobacter Infections - ethnology
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - classification
Helicobacter pylori - genetics
Helicobacter pylori - isolation & purification
Human bacterial diseases
Humans
Infections
Infectious diseases
Internal Medicine
Malaysia - epidemiology
Malaysia - ethnology
Medical Microbiology
Medical sciences
Medicine
Minority & ethnic groups
Molecular Sequence Data
Pathogens
Polymerase Chain Reaction
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid
Sequence Analysis, DNA
Ulcers
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Summary:We have defined DNA repeat variability in the 3'-terminus of the cagA gene of Helicobacter pylori strains from Malaysian patients of different ethnicities. We identified different alleles based on the EPIYA repeats. cagA types A-B-D and A-B-B-D are more similar to the sequence of Japanese strains, whereas cagA types A-B-C, A-B-C-C, A-B and A-C displayed similarity to strain 26695 sequences. A significant association was found between cagA genotypes and patients' ethnicity, with cagA type A-B-D being predominantly isolated from Chinese patients and cagA type A-B-C from Malays and Indians. Our data further corroborate the possibility that variant biological activity of CagA may affect the host specificity and/or pathogenicity of H. pylori.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-009-0712-x