Increased sFlt-1 to PlGF ratio in women who subsequently develop preeclampsia

The purpose of this study was to determine whether the levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) are altered during the second trimester in the plasma of women who subsequently develop preeclampsia. We performed a case-control study to compare the levels...

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Bibliographic Details
Published in:Journal of Korean medical science 2007-10, Vol.22 (5), p.873-877
Main Authors: Kim, Shin-Young, Ryu, Hyun-Mee, Yang, Jae-Hyug, Kim, Moon-Young, Han, Jung-Yeol, Kim, Joo-Oh, Chung, Jin-Hoon, Park, So-Yeon, Lee, Moon-Hee, Kim, Do-Jin
Format: Article
Language:English
Subjects:
Adult
Biomarkers - metabolism
Case-Control Studies
Female
Humans
Immunoassay
Middle Aged
Original
Placenta - metabolism
Placenta Growth Factor
Pre-Eclampsia - diagnosis
Pre-Eclampsia - metabolism
Pregnancy
Pregnancy Proteins - biosynthesis
Pregnancy Trimester, Second
ROC Curve
Sensitivity and Specificity
Vascular Endothelial Growth Factor Receptor-1 - biosynthesis
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Summary:The purpose of this study was to determine whether the levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) are altered during the second trimester in the plasma of women who subsequently develop preeclampsia. We performed a case-control study to compare the levels of sFlt-1 and PlGF in the preeclamptic (n=46) and normal pregnant women (n=100). The maternal plasma levels of sFlt-1 and PlGF were measured by enzyme-linked immunosorbent assay. The sFlt-1 levels were significantly higher in the preeclamptic women than in normal controls (p
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2007.22.5.873