Sex-dependent effect of cyclooxygenase-2 inhibition on mouse spatial memory

Cyclooxygenase (COX)-2 is constitutively expressed in neurons of the hippocampus and neocortex. Therefore, non-steroidal anti-inflammatory drugs (NSAIDs) targeting inflammation-induced COX-2 in the periphery and the central nervous system may also affect cognitive function mediated by basal COX-2 ac...

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Bibliographic Details
Published in:Behavioural brain research 2009-05, Vol.199 (2), p.355-359
Main Authors: Guzmán, Cristina B., Graham, Kaylan A., Grace, Lindsey A., Moore, Amy H.
Format: Article
Language:English
Subjects:
Animals
Behavioral psychophysiology
Biological and medical sciences
C57BL/6J mice
Cyclooxygenase 2 - physiology
Cyclooxygenase Inhibitors - pharmacology
Cyclooxygenase-2
Female
Fundamental and applied biological sciences. Psychology
Male
Memory - drug effects
Mice
Mice, Inbred C57BL
Nitrobenzenes - pharmacology
Non-steroidal anti-inflammatory drugs
NS-398
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Sex Characteristics
Sulfonamides - pharmacology
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Summary:Cyclooxygenase (COX)-2 is constitutively expressed in neurons of the hippocampus and neocortex. Therefore, non-steroidal anti-inflammatory drugs (NSAIDs) targeting inflammation-induced COX-2 in the periphery and the central nervous system may also affect cognitive function mediated by basal COX-2 activity. We report that systemic administration of the selective COX-2 inhibitor NS-398 6 h prior to behavioral assessment does not influence spatial acquisition or retention in male C57BL/6J mice. However, we observed impaired spatial retention in female mice treated with NS-398, suggesting a sex-dependent role of COX-2 in spatial memory of mice.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2009.01.005