The expression of thymidine phosphorylase in cancer-infiltrating inflammatory cells in stomach cancer

Thymidine phosphorylase (TP) has shown to be up-regulated in several cancers and to play a role in angiogenesis and invasion. Most studies regarding TP have focused on cancer cells. Recently, evidences suggest that TP in cancer-infiltrating inflammatory cells (CIICs) also affect the cancer cell beha...

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Bibliographic Details
Published in:Journal of Korean medical science 2007-09, Vol.22 Suppl (Suppl), p.S109-S114
Main Authors: Jang, Joung Soon, Lee, Won Sup, Lee, Jong Seok, Kim, Hwal Woong, Ko, Gyung Hyuck, Ha, Woo Song
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Humans
Immunohistochemistry
Inflammation - enzymology
Inflammation - pathology
Kaplan-Meier Estimate
Lymphatic Metastasis
Lymphocytes, Tumor-Infiltrating - enzymology
Lymphocytes, Tumor-Infiltrating - pathology
Male
Microcirculation - pathology
Middle Aged
Neovascularization, Pathologic
Original
Prognosis
Stomach Neoplasms - blood supply
Stomach Neoplasms - enzymology
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Thymidine Phosphorylase - metabolism
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Summary:Thymidine phosphorylase (TP) has shown to be up-regulated in several cancers and to play a role in angiogenesis and invasion. Most studies regarding TP have focused on cancer cells. Recently, evidences suggest that TP in cancer-infiltrating inflammatory cells (CIICs) also affect the cancer cell behavior. To evaluate the significance of TP expression of CIICs in gastric cancer, we assessed TP expression of cancer cells and CIICs separately using immunohistochemical assay on 116 paraffin-embedded tissue samples from stomach cancer patients and investigated their clinical significance. When subjects were divided into 4 groups according to the TP expression: cancer/matrix (+/+), C/M (+/-), C/M (-/+), and C/M (-/-), intratumoral microvessel density scores were higher in the C/M (+/-) group than in the C/M (-/-) group (p=0.02). For lymph node metastasis and survival, there were no significant differences among the 4 groups. However, there were significant differences in survival (p=0.035) and LN metastasis (p=0.023) between the two groups divided by TP expression of CIICs alone irrespective of TP expression of cancer cells. Taken together, this study suggested the TP expression in CIICs could affect lymph node metastasis and patients' survival in gastric cancer.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2007.22.s.s109