A case of post-streptococcal glomerulonephritis with diffuse alveolar hemorrhage

Acute post-streptococcal glomerulonephritis (PSGN) is characterized by an abrupt onset of edema, hypertension, and hematuria. Life-threatening diffuse alveolar hemorrhage (DAH) is rarely associated with acute PSGN. There have been only two reported cases worldwide, and no case has been reported prev...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Korean medical science 2007-12, Vol.22 (6), p.1074-1078
Main Authors: Sung, Hye Young, Lim, Chang Hoon, Shin, Mi Jung, Kim, Byung Soo, Kim, Young Ok, Song, Ho Chul, Kim, Suk Young, Choi, Euy Jin, Chang, Yoon Sik, Bang, Byung Kee
Format: Article
Language:English
Subjects:
Biopsy
Case Report
Female
Glomerulonephritis - etiology
Hemorrhage - etiology
Humans
Kidney - pathology
Lung Diseases - etiology
Middle Aged
Pulmonary Alveoli
Streptococcal Infections - complications
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acute post-streptococcal glomerulonephritis (PSGN) is characterized by an abrupt onset of edema, hypertension, and hematuria. Life-threatening diffuse alveolar hemorrhage (DAH) is rarely associated with acute PSGN. There have been only two reported cases worldwide, and no case has been reported previously in Korea. Here, we present a patient who clinically presented with pulmonary-renal syndrome; the renal histology revealed post-infectious glomerulonephritis of immune complex origin. A 59-yr-old woman was admitted with oliguria and hemoptysis two weeks after pharyngitis. Renal insufficiency rapidly progressed, and respiratory distress developed. Chest radiography showed acute progressive bilateral pulmonary infiltrates. The clinical presentation suggested DAH with PSGN. Three days after treatment with high-dose steroids, the respiratory distress and pulmonary infiltrates resolved. Electron microscopy of a renal biopsy specimen sample revealed diffuse proliferative glomerulonephritis with characteristic subendothelial deposits of immune complex (''hump''). The renal function of the patient was restored, and the serum creatinine level was normalized after treatment.
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2007.22.6.1074