Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint

The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle. Popular models propose that checkpoint proteins associate with kinetochores to produce a “wait anaphase” signal that inhibits anaphase. Recent data suggest that a two-state switch res...

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Bibliographic Details
Published in:Developmental cell 2008-04, Vol.14 (4), p.474-479
Main Authors: Burke, Daniel J., Stukenberg, P. Todd
Format: Article
Language:English
Subjects:
Animals
Cell Cycle - physiology
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Genes, cdc
Humans
Kinetochores - metabolism
Microtubules - metabolism
Models, Biological
Protein Binding
Protein Kinases - metabolism
Signal Transduction - physiology
Spindle Apparatus - metabolism
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Summary:The spindle checkpoint blocks cell-cycle progression until chromosomes are properly attached to the mitotic spindle. Popular models propose that checkpoint proteins associate with kinetochores to produce a “wait anaphase” signal that inhibits anaphase. Recent data suggest that a two-state switch results from using the same kinetochore proteins to bind microtubules and checkpoint proteins. At least eight protein kinases are implicated in spindle checkpoint signaling, arguing that a traditional signal transduction cascade is integral to spindle checkpoint signaling.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2008.03.015