Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance

• Published in: Advances in enzyme regulation 2007, Vol.47 (1), p.64-103
• Main Authors: McCubrey, James A, Steelman, Linda S, Franklin, Richard A, Abrams, Steven L, Chappell, William H, Wong, Ellis W T, Lehmann, Brian D, Terrian, David M, Basecke, Jorg, Stivala, Franca, Libra, Massimo, Evangelisti, Camilla, Martelli, Alberto M
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - pharmacology; Cell Line, Tumor; Drug Delivery Systems - methods; Drug Resistance, Neoplasm - physiology; Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors; Extracellular Signal-Regulated MAP Kinases - biosynthesis; Extracellular Signal-Regulated MAP Kinases - genetics; Hematologic Neoplasms - drug therapy; Hematologic Neoplasms - enzymology; Hematologic Neoplasms - metabolism; Mice; Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases - biosynthesis; Mitogen-Activated Protein Kinase Kinases - genetics; Phosphatidylinositol 3-Kinases - antagonists & inhibitors; Phosphatidylinositol 3-Kinases - biosynthesis; Phosphatidylinositol 3-Kinases - genetics; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - biosynthesis; Proto-Oncogene Proteins c-akt - genetics; raf Kinases - antagonists & inhibitors; raf Kinases - biosynthesis; raf Kinases - genetics; raf Kinases - metabolism; Signal Transduction - drug effects; Signal Transduction - physiology; Tumor Suppressor Protein p53 - antagonists & inhibitors; Tumor Suppressor Protein p53 - biosynthesis; Tumor Suppressor Protein p53 - genetics
• ISSN: 0065-2571; 1873-2437
• DOI: 10.1016/j.advenzreg.2006.12.013