Comparative effects of antiresorptive agents on bone mineral density and bone turnover in postmenopausal women

Postmenopausal osteoporosis is a common clinical entity; its complications represent a significant burden to society. In recent years the choice of therapies available for the treatment of postmenopausal osteoporosis has increased dramatically. There are a number of antiresorptive agents currently a...

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Bibliographic Details
Published in:Clinical interventions in aging 2006-01, Vol.1 (4), p.377-387
Main Authors: Jordan, Natasha, Barry, Maurice, Murphy, Eithne
Format: Article
Language:English
Subjects:
Bone density
Bone Density - drug effects
Bone Density Conservation Agents - adverse effects
Bone Density Conservation Agents - pharmacology
Bone Density Conservation Agents - therapeutic use
Bone Resorption - prevention & control
Estrogen Replacement Therapy - methods
Female
Fractures, Bone - prevention & control
Hormone replacement therapy
Humans
Middle Aged
Osteoporosis
Osteoporosis, Postmenopausal - drug therapy
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Summary:Postmenopausal osteoporosis is a common clinical entity; its complications represent a significant burden to society. In recent years the choice of therapies available for the treatment of postmenopausal osteoporosis has increased dramatically. There are a number of antiresorptive agents currently available including hormone replacement therapy (HRT), selective estrogen receptor modulators (SERMs), bisphosphonates, and dual action bone agents. It is difficult to truly compare these therapies given the lack of direct head-to head studies. The efficacy of antiresorptive therapies can be assessed in a number of ways including measurement of bone mineral density (BMD), assessment of bone turnover markers, and fracture reduction. Other important factors include ease of administration and consequent patient compliance. This article reviews the currently available antiresorptive agents and their effects on the above outcome measures.
ISSN:1176-9092
1178-1998
DOI:10.2147/ciia.2006.1.4.377