The role of glucocorticoids for spiral ganglion neuron survival

Abstract Glucocorticoids, which are steroidal stress hormones, have a broad array of biological functions. Synthetic glucocorticoids are frequently used therapeutically for many pathologic conditions, including diseases of the inner ear; however, their exact functions in the cochlea are not complete...

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Bibliographic Details
Published in:Brain research 2009-06, Vol.1277, p.3-11
Main Authors: Jin, David Xu, Lin, Zhaoyu, Lei, Debin, Bao, Jianxin
Format: Article
Language:English
Subjects:
Age-related hearing loss
Animals
Biological and medical sciences
Cell Survival - physiology
Cochlea - metabolism
Corticosteroid
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Fundamental and applied biological sciences. Psychology
Glucocorticoid
Glucocorticoids - genetics
Glucocorticoids - metabolism
Hair cell
Humans
Medical sciences
Neurology
Neurons - physiology
Noise-induced hearing loss
Non tumoral diseases
Otorhinolaryngology. Stomatology
Signal Transduction - physiology
Spiral Ganglion - cytology
Spiral Ganglion - metabolism
Spiral ganglion neuron
Vertebrates: nervous system and sense organs
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Summary:Abstract Glucocorticoids, which are steroidal stress hormones, have a broad array of biological functions. Synthetic glucocorticoids are frequently used therapeutically for many pathologic conditions, including diseases of the inner ear; however, their exact functions in the cochlea are not completely understood. Recent work has clearly demonstrated the presence of glucocorticoid signaling pathways in the cochlea and elucidated their protective roles against noise-induced hearing loss. Furthermore, indirect evidence suggests the involvement of glucocorticoids in age-related loss of spiral ganglion neurons and extensive studies in the central nervous system demonstrate profound effects of glucocorticoids on neuronal functions. With the advancement of recent pharmacologic and genetic tools, the role of these pathways in the survival of spiral ganglion neurons after noise exposure and during aging should be revealed.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2009.02.017