Dopamine and inhibitory action control: evidence from spontaneous eye blink rates

The inhibitory control of actions has been claimed to rely on dopaminergic pathways. Given that this hypothesis is mainly based on patient and drug studies, some authors have questioned its validity and suggested that beneficial effects of dopaminergic stimulants on response inhibition may be limite...

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Published in:Experimental brain research 2009-07, Vol.196 (3), p.467-474
Main Authors: Colzato, Lorenza Serena, van den Wildenberg, Wery P. M, van Wouwe, Nelleke C, Pannebakker, Merel M, Hommel, Bernhard
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blinking - physiology
Dopamine
Electrooculography - methods
Eye and associated structures. Visual pathways and centers. Vision
Eye Movements - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Inhibition (Psychology)
Male
Models, Biological
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Neurology
Neurosciences
Patients
Photic Stimulation - methods
Reaction Time - physiology
Research Note
Schizophrenia
Time Factors
Vertebrates: nervous system and sense organs
Young Adult
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description The inhibitory control of actions has been claimed to rely on dopaminergic pathways. Given that this hypothesis is mainly based on patient and drug studies, some authors have questioned its validity and suggested that beneficial effects of dopaminergic stimulants on response inhibition may be limited to cases of suboptimal inhibitory functioning. We present evidence that, in carefully selected healthy adults, spontaneous eyeblink rate, a marker of central dopaminergic functioning, reliably predicts the efficiency in inhibiting unwanted action tendencies in a stop-signal task. These findings support the assumption of a modulatory role for dopamine in inhibitory action control.
doi_str_mv 10.1007/s00221-009-1862-x
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recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2700244
source Social Science Premium Collection; Springer Link
subjects Adult
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blinking - physiology
Dopamine
Electrooculography - methods
Eye and associated structures. Visual pathways and centers. Vision
Eye Movements - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Inhibition (Psychology)
Male
Models, Biological
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Neurology
Neurosciences
Patients
Photic Stimulation - methods
Reaction Time - physiology
Research Note
Schizophrenia
Time Factors
Vertebrates: nervous system and sense organs
Young Adult
title Dopamine and inhibitory action control: evidence from spontaneous eye blink rates
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