Plasmodium yoelii: Adverse outcome of non-lethal P. yoelii malaria during co-infection with Schistosoma mansoni in BALB/c mouse model

Plasmodium yoelii and Schistosoma mansoni co-infections were studied in female BALB/c mice aged 4–6weeks to determine the effect of time and stage of concomitant infections on malaria disease outcome. Patent S. mansoni infection in BALB/c mice increased malaria peak parasitemia and caused death from...

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Bibliographic Details
Published in:Experimental parasitology 2009-07, Vol.122 (3), p.254-259
Main Authors: Sangweme, Davison, Shiff, Clive, Kumar, Nirbhay
Format: Article
Language:English
Subjects:
Anemia - etiology
Animals
Anthelmintics - therapeutic use
BALB/c mice
Biological and medical sciences
Co-infection
Disease Models, Animal
Female
Fundamental and applied biological sciences. Psychology
Hematocrit
Hepatomegaly
Life cycle. Host-agent relationship. Pathogenesis
Malaria - complications
Malaria - drug therapy
Malaria - mortality
Mice
Mice, Inbred BALB C
Parasitemia - parasitology
Patent infection
Plasmodium yoelii
Praziquantel - therapeutic use
Protozoa
PZQ, praziquantel
Schistosoma mansoni
Schistosomiasis mansoni - complications
Schistosomiasis mansoni - drug therapy
Splenomegaly
Treatment Outcome
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Summary:Plasmodium yoelii and Schistosoma mansoni co-infections were studied in female BALB/c mice aged 4–6weeks to determine the effect of time and stage of concomitant infections on malaria disease outcome. Patent S. mansoni infection in BALB/c mice increased malaria peak parasitemia and caused death from an otherwise non-lethal, self-resolving P. yoelii malaria infection. Exacerbation of malaria parasitemia occurred during both pre-patent and patent S. mansoni infection resulting in a delay of 4–8days in malaria parasite resolution in co-infected mice. Praziquantel administered to mice with patent schistosome infection protected from fatal outcome during co-infection. However, this treatment did not completely clear the worm infestation, nor did it reduce the peak malaria parasitemia reached, which was nonetheless resolved completely. Hepatosplenomegaly was more marked in schistosome and malaria co-infected mice compared to either infection separately. The results suggest a complex relationship between schistosome co-infection and malaria disease outcome in which the timing of malaria infection in relation to schistosome acquisition is critical to disease outcome and pathology.
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2009.04.003