Gene therapy： Regulations, ethics and its practicalities in liver disease

Gene therapy is a new and promising approach which opens a new door to the treatment of human diseases. By direct transfer of genetic materials to the target cells, it could exert functions on the level of genes and molecules. It is hoped to be widely used in the treatment of liver disease, especial...

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Published in:World journal of gastroenterology : WJG 2008-04, Vol.14 (15), p.2303-2307
Main Authors: Jin, Xi, Yang, Yi-Da, Li, You-Ming
Format: Article
Language:English
Subjects:
Animals
Diffusion of Innovation
Genetic Therapy - adverse effects
Genetic Therapy - ethics
Genetic Therapy - legislation & jurisprudence
Genetic Therapy - trends
Genetic Vectors
Government Regulation
Humans
Liver Diseases - genetics
Liver Diseases - therapy
Liver Neoplasms - genetics
Liver Neoplasms - therapy
Review
Transduction, Genetic
Treatment Outcome
基因治疗
带菌者
肝疾病
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cited_by cdi_FETCH-LOGICAL-c435t-f71b59473e70262f87f55d64fdea39027a552acb11c48e87012622164c932fbc3
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container_title World journal of gastroenterology : WJG
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creator Jin, Xi
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description Gene therapy is a new and promising approach which opens a new door to the treatment of human diseases. By direct transfer of genetic materials to the target cells, it could exert functions on the level of genes and molecules. It is hoped to be widely used in the treatment of liver disease, especially hepatic tumors by using different vectors encoding the aim gene for anti-tumor activity by activating primary and adaptive immunity, inhibiting oncogene and angiogenesis. Despite the huge curative potential shown in animal models and some pilot clinical trials, gene therapy has been under fierce discussion since its birth in academia and the public domain because of its unexpected side effects and ethical problems. There are other challenges arising from the technique itself like vector design, administration route test and standard protocol exploration. How well we respond will decide the fate of gene therapy clinical medical practice.
doi_str_mv 10.3748/wjg.14.2303
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identifier ISSN: 1007-9327
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subjects Animals
Diffusion of Innovation
Genetic Therapy - adverse effects
Genetic Therapy - ethics
Genetic Therapy - legislation & jurisprudence
Genetic Therapy - trends
Genetic Vectors
Government Regulation
Humans
Liver Diseases - genetics
Liver Diseases - therapy
Liver Neoplasms - genetics
Liver Neoplasms - therapy
Review
Transduction, Genetic
Treatment Outcome
基因治疗
带菌者
肝疾病
title Gene therapy： Regulations, ethics and its practicalities in liver disease
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