An updated review of tyrosinase inhibitors

Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor...

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Published in:International journal of molecular sciences 2009-05, Vol.10 (6), p.2440-2475
Main Author: Chang, Te-Sheng
Format: Article
Language:English
Subjects:
Benzaldehydes - chemistry
Benzaldehydes - metabolism
Benzoates - chemistry
Benzoates - metabolism
Biological Products - chemistry
Biological Products - metabolism
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - metabolism
Melanins - metabolism
Monophenol Monooxygenase - antagonists & inhibitors
Monophenol Monooxygenase - metabolism
Polyphenols - chemistry
Polyphenols - metabolism
Protein Binding
Review
Steroids - chemistry
Steroids - metabolism
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cited_by cdi_FETCH-LOGICAL-c477t-40d0e79a5396e0edcdb308dea3a7305e8328f0bf34123a4e80d27777b14680053
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description Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.
doi_str_mv 10.3390/ijms10062440
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source Publicly Available Content Database; PubMed Central
subjects Benzaldehydes - chemistry
Benzaldehydes - metabolism
Benzoates - chemistry
Benzoates - metabolism
Biological Products - chemistry
Biological Products - metabolism
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - metabolism
Melanins - metabolism
Monophenol Monooxygenase - antagonists & inhibitors
Monophenol Monooxygenase - metabolism
Polyphenols - chemistry
Polyphenols - metabolism
Protein Binding
Review
Steroids - chemistry
Steroids - metabolism
title An updated review of tyrosinase inhibitors
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