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Adhesions in a murine flexor tendon graft model: Autograft versus allograft reconstruction

Reconstruction of flexor tendons often results in adhesions that compromise joint flexion. Little is known about the factors involved in the formation of flexor tendon graft adhesions. In this study, we developed and characterized a novel mouse model of flexor digitorum longus (FDL) tendon reconstru...

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Bibliographic Details
Published in:Journal of orthopaedic research 2008-06, Vol.26 (6), p.824-833
Main Authors: Hasslund, Sys, Jacobson, Justin A., Dadali, Tulin, Basile, Patrick, Ulrich-Vinther, Michael, Søballe, Kjeld, Schwarz, Edward M., O'Keefe, Regis J., Mitten, David J., Awad, Hani A.
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Language:English
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Summary:Reconstruction of flexor tendons often results in adhesions that compromise joint flexion. Little is known about the factors involved in the formation of flexor tendon graft adhesions. In this study, we developed and characterized a novel mouse model of flexor digitorum longus (FDL) tendon reconstruction with live autografts or reconstituted freeze‐dried allografts. Grafted tendons were evaluated at multiple time points up to 84 days post‐reconstruction. To assess the flexion range of the metatarsophalangeal joint, we developed a quantitative outcome measure proportional to the resistance to tendon gliding due to adhesions, which we termed the Gliding Coefficient. At 14 days post‐grafting, the Gliding Coefficient was 29‐ and 26‐fold greater than normal FDL tendon for both autografts and allografts, respectively (p 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.20531