Effect of Chlorotriphenyl Derivatives of Sn and Pb upon Biophysical Properties of Membranes

Biophysical activity of two twin organometallic compounds Triphenyltin chloride (TPhT) and Triphenyllead chloride (TPhL) in their interreaction with model membranes, as well as with yeast cells Saccharomyces cerevisiae, was investigated. Four measurement methods were used in the experiments: two phy...

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Bibliographic Details
Published in:BioMed research international 2009-01, Vol.2009 (2009), p.1-7
Main Authors: Man, Dariusz, Podolak, Marian, Engel, Grzegorz, Boniewska, Ewa
Format: Article
Language:English
Subjects:
Acids
Apoptosis
Biophysical Phenomena
Cell Membrane - chemistry
Cell Membrane - drug effects
Cell Membrane - physiology
Cell Survival - drug effects
Chemical properties
Electron Spin Resonance Spectroscopy
Experiments
Lauric Acids - chemistry
Lead compounds
Lipid membranes
Liposomes - chemistry
Liposomes - metabolism
Membrane Potentials - drug effects
Methods
Organisms
Organometallic compounds
Organometallic Compounds - pharmacology
Organotin Compounds - pharmacology
Properties
Saccharomyces cerevisiae - drug effects
Studies
Time Factors
Tin compounds
Yeast
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Summary:Biophysical activity of two twin organometallic compounds Triphenyltin chloride (TPhT) and Triphenyllead chloride (TPhL) in their interreaction with model membranes, as well as with yeast cells Saccharomyces cerevisiae, was investigated. Four measurement methods were used in the experiments: two physical methods (spin probes method and the electric method); two biological methods (minimal inhibitory concentration /MIC/ and yeast survival test). It has been found that the activity of TPhT in interaction with model membranes and yeast cells is distinctly greater than that of TPhL. The activity manifests itself by considerable increase in the fluidity of the middle part of liposome bilayer, change in the polarization direction of the transmembrane voltage of filters impregnated with lauric acid, and in complete inhibition of growth of yeast cells at the concentration of 5 μg/mL.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2009/969480