Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians

Summary South Asian immigrants in western societies exhibit a high burden of diabetes and subsequent vascular complications. Diabetic vascular complications are associated with vascular inflammation. We hypothesize that enhanced complement activation is involved. Therefore, levels of complement C3 a...

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Bibliographic Details
Published in:Clinical and experimental immunology 2009-07, Vol.157 (1), p.98-103
Main Authors: Siezenga, M. A., Chandie Shaw, P. K., Van Der Geest, R. N., Mollnes, T. E., Daha, M. R., Rabelink, T. J., Berger, S. P.
Format: Article
Language:English
Subjects:
Adult
Aged
Albuminuria - blood
Albuminuria - immunology
Analytical, structural and metabolic biochemistry
Asia, Southeastern - ethnology
Asian Continental Ancestry Group
Biological and medical sciences
Biomarkers - blood
cardiovascular
Cardiovascular Diseases - immunology
Case-Control Studies
complement
Complement Activation
Complement C3 - immunology
Complement Membrane Attack Complex - analysis
diabetes
Diabetes Mellitus, Type 2 - immunology
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Middle Aged
Netherlands
Risk
South Asian
Statistics, Nonparametric
Translational Studies
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Summary:Summary South Asian immigrants in western societies exhibit a high burden of diabetes and subsequent vascular complications. Diabetic vascular complications are associated with vascular inflammation. We hypothesize that enhanced complement activation is involved. Therefore, levels of complement C3 and SC5b‐9 – the soluble end product of complement activation – in a group of 200 South Asians were compared with an age‐ and sex‐matched control group of native Caucasians. In addition, the association between complement levels and albuminuria, an indicator of renal damage and a cardiovascular risk marker, was assessed in the diabetic South Asian group. Compared with native Caucasians, South Asians had significantly higher levels of both serum C3 and plasma SC5b‐9, even when only non‐diabetic South Asians were considered. Diabetic South Asians had significantly higher C3 levels compared with non‐diabetic South Asians. In diabetic South Asians, higher levels of SC5b‐9 were associated with an increased prevalence of albuminuria (odds ratio 5·4, 95% confidence interval 1·8–15·8). These results suggest that enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2009.03959.x